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Issue 40, 2018
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Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

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Abstract

Based on the intramolecular Heck-type reaction, a convenient and efficient strategy to construct functionalized ynones by a palladium-catalyzed cascade annulation reaction has been developed. This reaction possesses good functional group compatibility, a broad substrate scope, and high atom- and step-economy. Furthermore, this approach could also be extended to direct alkynylation that gave another route to synthesize dihydrobenzofurans.

Graphical abstract: Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

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Publication details

The article was received on 27 Aug 2018, accepted on 18 Sep 2018 and first published on 19 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02092B
Citation: Org. Biomol. Chem., 2018,16, 7383-7392
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    Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

    M. Hu, Y. Gao, W. Wu, J. Li, C. Li, H. Zhang and H. Jiang, Org. Biomol. Chem., 2018, 16, 7383
    DOI: 10.1039/C8OB02092B

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