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Issue 41, 2018
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One-pot synthesis of polyfunctionalized quinolines via a copper-catalyzed tandem cyclization

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Abstract

An efficient one-pot approach for the synthesis of polyfunctionalized quinolines was developed via a sequence of copper-catalyzed coupling reaction/propargyl-allenyl isomerization/aza-electrocyclization. Easily available starting materials, mild conditions, and a wide substrate scope make this approach potentially useful.

Graphical abstract: One-pot synthesis of polyfunctionalized quinolines via a copper-catalyzed tandem cyclization

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Publication details

The article was received on 24 Aug 2018, accepted on 27 Sep 2018 and first published on 28 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02078G
Citation: Org. Biomol. Chem., 2018,16, 7657-7662

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    One-pot synthesis of polyfunctionalized quinolines via a copper-catalyzed tandem cyclization

    D. Chen, X. Sun, Y. Shan and J. You, Org. Biomol. Chem., 2018, 16, 7657
    DOI: 10.1039/C8OB02078G

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