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Issue 39, 2018
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Suzuki–Miyaura coupling of unstrained ketones via chelation-assisted C–C bond cleavage

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Abstract

Herein, we report that unstrained ketones can be efficiently employed as electrophiles in Suzuki–Miyaura reactions via catalytic activation of unstrained C–C bonds assist by an N-containing directing group. A wide range of aromatic ketones directly coupled with boronic ester with excellent functional group tolerance. This strategy provides an alternative and versatile approach to constructing biaryls from unstrained ketones.

Graphical abstract: Suzuki–Miyaura coupling of unstrained ketones via chelation-assisted C–C bond cleavage

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Publication details

The article was received on 24 Aug 2018, accepted on 18 Sep 2018 and first published on 19 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02075B
Citation: Org. Biomol. Chem., 2018,16, 7174-7177
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    Suzuki–Miyaura coupling of unstrained ketones via chelation-assisted C–C bond cleavage

    C. Jiang, Z. Zheng, T. Yu and H. Wei, Org. Biomol. Chem., 2018, 16, 7174
    DOI: 10.1039/C8OB02075B

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