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Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons

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Abstract

A palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons with [11C]NH4CN/NH3 has been developed using bench-stable and readily available reagents. The method showed excellent functional-group tolerance, and allowed the highly efficient synthesis of a wide range of [11C]cyanoarenes, including PET tracers for aromatase imaging. A mechanistic study of the 11C-cyanation suggests the instantaneous formation of a mono[11C]cyanopalladium(II) complex that reacts smoothly with arylborons.

Graphical abstract: Palladium(ii)-mediated rapid 11C-cyanation of (hetero)arylborons

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Publication details

The article was received on 21 Aug 2018, accepted on 01 Oct 2018 and first published on 02 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02049C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons

    Z. Zhang, T. Niwa, Y. Watanabe and T. Hosoya, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02049C

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