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Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction

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Abstract

The one-pot protocol by the dendritic copper powder-mediated Knoevenagel condensation/annelation is delineated here for the synthesis of 3-amido-2-quinolones. It is practical with moisture tolerance and easy setup, and is compatible with many functional groups under mild conditions. This method was applied for the preparation of the key intermediates of biologically relevant 3-amido-2-quinolones.

Graphical abstract: Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction

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Publication details

The article was received on 15 Aug 2018, accepted on 01 Oct 2018 and first published on 02 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB01994K
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction

    B. H. Ahn, I. Y. Lee and H. N. Lim, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01994K

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