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Formal reductive addition of acetonitrile to aldehydes and ketones

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Abstract

An efficient and highly productive rhodium-catalyzed method for the synthesis of nitriles employing aldehydes or ketones, methyl cyanoacetate, water and carbon monoxide as starting materials has been developed. Simple rhodium chloride without any ligands can be used. The fine tuning of the substrate can lead to the activity higher than 5000 TON.

Graphical abstract: Formal reductive addition of acetonitrile to aldehydes and ketones

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Publication details

The article was received on 15 Aug 2018, accepted on 27 Sep 2018 and first published on 28 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01992D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Formal reductive addition of acetonitrile to aldehydes and ketones

    K. Muratov, E. Kuchuk, S. Vellalath, O. I. Afanasyev, A. P. Moskovets, G. Denisov and D. Chusov, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01992D

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