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Issue 39, 2018
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Iron-catalysed carbene-transfer reactions of diazo acetonitrile

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Abstract

A continuous-flow protocol for the synthesis of diazo acetonitrile was developed. It was further applied in iron-catalysed insertion reactions of diazo acetonitrile into N–H and S–H bonds to yield valuable α-substituted acetonitrile, including gram-scale synthesis.

Graphical abstract: Iron-catalysed carbene-transfer reactions of diazo acetonitrile

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Publication details

The article was received on 15 Aug 2018, accepted on 20 Sep 2018 and first published on 20 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB01991F
Citation: Org. Biomol. Chem., 2018,16, 7129-7133
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    Iron-catalysed carbene-transfer reactions of diazo acetonitrile

    C. Empel, K. J. Hock and R. M. Koenigs, Org. Biomol. Chem., 2018, 16, 7129
    DOI: 10.1039/C8OB01991F

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