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Issue 39, 2018
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Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones

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Abstract

An organocatalytic enantioselective Tamura cycloaddition between homophthalic anhydrides and 2-arylidene-1,3-indanediones has been developed. With 2 mol% of commercially available (DHQD)2PYR, a wide range of enantioenriched spiro-1,3-indanedione derivatives were obtained in good-to-excellent yields (68–98%), excellent diastereoselectivities (99 : 1 dr) and moderate-to-excellent enantioselectivities (up to 95% ee).

Graphical abstract: Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones

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Publication details

The article was received on 13 Aug 2018, accepted on 18 Sep 2018 and first published on 19 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01970C
Citation: Org. Biomol. Chem., 2018,16, 7214-7222
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    Catalytic asymmetric Tamura cycloaddition of homophthalic anhydrides with 2-arylidene-1,3-diones

    H. Xu, F. Sha, Q. Li and X. Wu, Org. Biomol. Chem., 2018, 16, 7214
    DOI: 10.1039/C8OB01970C

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