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Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

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Abstract

In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficiently deacidify lysosomes. In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH.

Graphical abstract: Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

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Publication details

The article was received on 10 Aug 2018, accepted on 10 Oct 2018 and first published on 11 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB01957F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

    X. Hong, X. Yu, K. Zhang and W. Chen, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01957F

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