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Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

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Abstract

A highly enantioselective fluorination of indanone-2-carboxylates catalyzed by a polystyrene-supported diphenylamine-linked bis(oxazoline) (PS-box)-Cu(OTf)2 complex has been developed in a continuous flow system. The supported complex exhibited extremely efficient catalytic performance with high activity, affording the corresponding products in excellent yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and more than 4000 turnover number (TON).

Graphical abstract: Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

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Publication details

The article was received on 09 Aug 2018, accepted on 28 Sep 2018 and first published on 28 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01943F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

    B. Wang, Y. Wang, Y. Jiang, M. Chu, S. Qi, W. Ju and D. Xu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01943F

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