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Issue 41, 2018
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Efficient synthesis of organic thioacetates in water

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Thioacetates as precursors of thiols are interesting starting points for synthesizing other organosulfur compounds. Herein, we propose a simple, efficient and fast method to obtain organic thioacetates using water as a solvent. Taking into account the great attention that has been paid toward environmentally friendly synthetic procedures in the past decades, we prove the role and the strength of the thioacetate anion as a nucleophile for nucleophilic displacement reactions in an aqueous medium. The reactions were carried out under pH control, to prevent the decomposition of the mesylate starting materials, using potassium carbonate as a safe and mild base. A simple work up allows products to be obtained with excellent yield and acceptable purity.

Graphical abstract: Efficient synthesis of organic thioacetates in water

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Publication details

The article was received on 03 Aug 2018, accepted on 27 Sep 2018 and first published on 27 Sep 2018

Article type: Paper
DOI: 10.1039/C8OB01896K
Citation: Org. Biomol. Chem., 2018,16, 7753-7759

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    Efficient synthesis of organic thioacetates in water

    F. Olivito, P. Costanzo, M. L. Di Gioia, M. Nardi, O. M. and A. Procopio, Org. Biomol. Chem., 2018, 16, 7753
    DOI: 10.1039/C8OB01896K

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