Issue 38, 2018
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes†

Ailada Charoenpol,a   Jatuporn Meesin,a   Onnicha Khaikate,a   Vichai Reutrakul,a   Manat Pohmakotr, ORCID logo a   Pawaret Leowanawat,a   Darunee Soorukram ORCID logo a  and  Chutima Kuhakarn ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
E-mail: chutima.kon@mahidol.ac.th

Abstract

A facile synthesis of various functionalized 3-substituted quinolin-2(1H)-ones through Ag(I) nitrate-catalyzed cyclization of o-alkynylisocyanobenzenes is described. The reaction allows rapid and convenient access to 3-substituted quinolin-2(1H)-one scaffolds in moderate to good yields.

Graphical abstract: Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes

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Article information

DOI
https://doi.org/10.1039/C8OB01882K
Article type
Paper
Submitted
03 Aug 2018
Accepted
13 Sep 2018
First published
14 Sep 2018

Org. Biomol. Chem., 2018,16, 7050-7054

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Synthesis of 3-substituted quinolin-2(1H)-ones via the cyclization of o-alkynylisocyanobenzenes

A. Charoenpol, J. Meesin, O. Khaikate, V. Reutrakul, M. Pohmakotr, P. Leowanawat, D. Soorukram and C. Kuhakarn, Org. Biomol. Chem., 2018, 16, 7050 DOI: 10.1039/C8OB01882K

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