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Issue 37, 2018
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Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

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Abstract

A novel and efficient metal free, redox-neutral method for the synthesis of secondary thiocarbamates by cross-coupling of readily available thiophenol and isocyanides has been developed. The present methodology exhibits a broad substrate scope with good to excellent yields without an additive/extra oxidant under mild reaction conditions catalyzed by inexpensive iodine as the catalyst.

Graphical abstract: Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

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Publication details

The article was received on 31 Jul 2018, accepted on 04 Sep 2018 and first published on 04 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB01855C
Citation: Org. Biomol. Chem., 2018,16, 8263-8266

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    Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

    R. S. Pathare, V. Patil, H. Kaur, A. K. Maurya, V. K. Agnihotri, S. Khan, N. Devunuri, A. Sharon and D. M. Sawant, Org. Biomol. Chem., 2018, 16, 8263
    DOI: 10.1039/C8OB01855C

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