Issue 37, 2018
From the journal:

Organic & Biomolecular Chemistry

Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates†

Ramdas S. Pathare, ORCID logo a   Vikas Patil,b   Harpreet Kaur,c   Antim K. Maurya,d   Vijai K. Agnihotri,d   Shahnawaz Khan,*e   Nagaraju Devunuri,b   Ashoke Sharon ORCID logo c  and  Devesh M. Sawant ORCID logo *a  

* Corresponding authors

a School of Chemical Sciences and Pharmacy, Central University of Rajasthan, NH8, Bandarsindri, Ajmer-305817, Rajasthan, India
E-mail: dms@curaj.ac.in

b Vignans Foundation for Science, Technology & Research, Vadlamudi, Guntur-522 213, Andhra Pradesh, India

c Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India

d Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh-176061, India

e Department of Chemistry, Bhupal Noble's University, Udaipur-313001, India
E-mail: khancdri@gmail.com

Abstract

A novel and efficient metal free, redox-neutral method for the synthesis of secondary thiocarbamates by cross-coupling of readily available thiophenol and isocyanides has been developed. The present methodology exhibits a broad substrate scope with good to excellent yields without an additive/extra oxidant under mild reaction conditions catalyzed by inexpensive iodine as the catalyst.

Graphical abstract: Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

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Article information

DOI
https://doi.org/10.1039/C8OB01855C
Article type
Communication
Submitted
31 Jul 2018
Accepted
04 Sep 2018
First published
04 Sep 2018

Org. Biomol. Chem., 2018,16, 8263-8266

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Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

R. S. Pathare, V. Patil, H. Kaur, A. K. Maurya, V. K. Agnihotri, S. Khan, N. Devunuri, A. Sharon and D. M. Sawant, Org. Biomol. Chem., 2018, 16, 8263 DOI: 10.1039/C8OB01855C

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