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Issue 47, 2018
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Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase

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Abstract

Tyrosinase, a copper-containing enzyme existing widely in plants, animals and microorganisms, usually serves as an important biomarker in melanoma, and is also related to hyperpigmentation of the skin, melasma, age spots and albinism. At present, only one bioluminescent probe has been applied to image tyrosinase in cells. Thus, it's of great significance to develop a new bioluminescent probe that can detect tyrosinase in living cells and in live animals. In the current work, we report a new BL probe, TyrBP-3, which not detect tyrosinase in vitro and in living cells, but can also visualize the level of tyrosinase activity in tumors of living animals. In summary, TyrBP-3 is the first bioluminescent probe that can image tyrosinase on a cellular level. Hence, we anticipate that TyrBP-3 can be a good tool to monitor tyrosinase in complex biosystems in the future.

Graphical abstract: Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase

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Publication details

The article was received on 24 Jul 2018, accepted on 08 Nov 2018 and first published on 12 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB01777H
Citation: Org. Biomol. Chem., 2018,16, 9197-9203
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    Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase

    C. Tang, L. Jin, Y. Lin, J. Su, Y. Sun, P. Liu, Q. Li, G. Wang, Z. Zhang, L. Du and M. Li, Org. Biomol. Chem., 2018, 16, 9197
    DOI: 10.1039/C8OB01777H

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