Issue 41, 2018

Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules

Abstract

Stereoselective synthesis of common C1–C19 skeletons of pentane macrolides strevertenes A and G possessing 10 stereogenic centers has been achieved using a flexible and convergent strategy. The salient features of this synthetic study include the Evans aldol reaction for the constructions of C2, C3, C13, and C14 centers, CBS reduction for the generation of a C7 center, Hoveyda–Grubbs cross olefin metathesis for the synthesis of C8–C9 bond, and Wittig olefination for the installation of C16–C19 conjugated olefins.

Graphical abstract: Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules

Supplementary files

Article information

Article type
Paper
Submitted
21 Jul 2018
Accepted
23 Aug 2018
First published
23 Aug 2018

Org. Biomol. Chem., 2018,16, 7595-7608

Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules

T. K. Kuilya, S. Das, D. Saha and R. K. Goswami, Org. Biomol. Chem., 2018, 16, 7595 DOI: 10.1039/C8OB01754A

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