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Issue 37, 2018
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Xylopsides A–D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana

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Abstract

Four unprecedented guaiane dimers, xylopsides A–D (1–4), were isolated and identified from the roots of Xylopia vielana. The structures of 1–4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1–4 showed two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.

Graphical abstract: Xylopsides A–D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana

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Publication details

The article was received on 16 Jul 2018, accepted on 07 Sep 2018 and first published on 07 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01689E
Citation: Org. Biomol. Chem., 2018,16, 7030-7034
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    Xylopsides A–D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana

    Y. Xie, Y. Guo, G. Wu, S. Zhu, T. Cheng, Y. Zhang, S. Yan, H. Jin and W. Zhang, Org. Biomol. Chem., 2018, 16, 7030
    DOI: 10.1039/C8OB01689E

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