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Issue 44, 2018
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Iridium-catalyzed [4 + 2] annulation of 1-arylindazolones with α-diazo carbonyl compounds: access to indazolone-fused cinnolines

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Abstract

An efficient one-pot Ir-catalyzed method was developed for the synthesis of indazolone-fused cinnolines by [4 + 2] annulation of 1-arylindazolones with α-diazo carbonyl compounds via sequential C–H activation/carbene insertion/cyclization in a tandem manner. This method has excellent tolerance towards electron-withdrawing and electron-donating functional groups on 1-arylindazolone. This method was also found to be applicable to cyclic α-diazo carbonyl compounds.

Graphical abstract: Iridium-catalyzed [4 + 2] annulation of 1-arylindazolones with α-diazo carbonyl compounds: access to indazolone-fused cinnolines

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Publication details

The article was received on 15 Jul 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB01681J
Citation: Org. Biomol. Chem., 2018,16, 8585-8595
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    Iridium-catalyzed [4 + 2] annulation of 1-arylindazolones with α-diazo carbonyl compounds: access to indazolone-fused cinnolines

    C. K. Mahesha, D. S. Agarwal, P. Karishma, D. Markad, S. K. Mandal and R. Sakhuja, Org. Biomol. Chem., 2018, 16, 8585
    DOI: 10.1039/C8OB01681J

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