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Issue 43, 2018
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Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds

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Abstract

Heterocyclic compounds bearing 1,2,3-triazole scaffolds have found wide application both in medicinal chemistry and materials science. In this paper, rhodium(III)-catalyzed triazole-directed alkylation reactions of arenes using diazo compounds as the alkylating agents are described. A number of polysubstituted arenes were provided from easily available materials in good yields under mild conditions. The reactions proceed via triazole-directed ortho C–H bond activation and subsequent carbene insertion originating from diazo compounds.

Graphical abstract: Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds

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Publication details

The article was received on 14 Jul 2018, accepted on 17 Oct 2018 and first published on 18 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB01673A
Citation: Org. Biomol. Chem., 2018,16, 8191-8195
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    Rhodium-catalyzed triazole-directed C–H bond functionalization of arenes with diazo compounds

    H. Wang, X. Yi, Y. Cui and W. Chen, Org. Biomol. Chem., 2018, 16, 8191
    DOI: 10.1039/C8OB01673A

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