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Issue 32, 2018
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Synthesis of 3-cyanomethylated coumarins by a visible-light-mediated direct cyanomethylation of aryl alkynoates

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Abstract

A visible-light-promoted, mild, and direct cyanomethylation of aryl alkynoates has been developed. This method provides a new strategy toward the synthesis of 3-cyanomethylated coumarins via a domino radical addition/5-exo cyclization/ester migration cascade reaction in moderate to good yields at room temperature. Converting the resulting products into various molecules exhibited the synthetic utility of the present methodology.

Graphical abstract: Synthesis of 3-cyanomethylated coumarins by a visible-light-mediated direct cyanomethylation of aryl alkynoates

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Article information


Submitted
27 Jun 2018
Accepted
19 Jul 2018
First published
20 Jul 2018

Org. Biomol. Chem., 2018,16, 5788-5792
Article type
Paper

Synthesis of 3-cyanomethylated coumarins by a visible-light-mediated direct cyanomethylation of aryl alkynoates

W. Zhang, C. Yang, Y. Pan, X. Li and J. Cheng, Org. Biomol. Chem., 2018, 16, 5788
DOI: 10.1039/C8OB01513A

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