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Issue 28, 2018
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Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides

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Abstract

A t-BuONa-mediated C–OH/P(O)–H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)–H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C–P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.

Graphical abstract: Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides

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Publication details

The article was received on 01 Jun 2018, accepted on 26 Jun 2018 and first published on 26 Jun 2018


Article type: Communication
DOI: 10.1039/C8OB01299G
Citation: Org. Biomol. Chem., 2018,16, 5090-5093
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    Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides

    L. Chen, Y. Zhu, T. Chen, L. Liu, J. Zhang and L. Han, Org. Biomol. Chem., 2018, 16, 5090
    DOI: 10.1039/C8OB01299G

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