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Issue 25, 2018
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Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale

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Abstract

A new and efficient Ionic Liquid-Supported Oligosaccharide Synthesis (ILSOS) strategy for an N-linked core pentasaccharide on a 10 g scale is reported. This new ILSOS includes a new spacer for an IL support, a new tagging strategy, and fast, efficient and orthogonal removal of the ionic-liquid support, producing the N-linked core pentasaccharide with direct applicability potential in a short time, with high yield and on a large gram scale.

Graphical abstract: Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale

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Publication details

The article was received on 04 May 2018, accepted on 04 Jun 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01046C
Citation: Org. Biomol. Chem., 2018,16, 4720-4727
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    Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale

    W. Li, Y. Gao, Q. Li and Z. Li, Org. Biomol. Chem., 2018, 16, 4720
    DOI: 10.1039/C8OB01046C

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