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Issue 25, 2018
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A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals

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Abstract

In this study, a single fluorescent probe (DPFP) containing a 1,8-naphthalimide dye and a homoallylamino group for imaging pH and formaldehyde (FA) has been developed that exhibits significant blue fluorescence (λem at 455 nm) under acidic pH conditions (pH < 7.0) and green fluorescence (λem at 555 nm) in the presence of FA, respectively. Furthermore, probe DPFP was successfully applied to image acidic lysosomes and exogenous or endogenous FA in living HeLa cells.

Graphical abstract: A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals

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Publication details

The article was received on 27 Apr 2018, accepted on 06 Jun 2018 and first published on 07 Jun 2018


Article type: Communication
DOI: 10.1039/C8OB00989A
Citation: Org. Biomol. Chem., 2018,16, 4628-4632
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    A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals

    Z. Xie, B. Yin, J. Shen, D. Hong, L. Zhu, J. Ge and Q. Zhu, Org. Biomol. Chem., 2018, 16, 4628
    DOI: 10.1039/C8OB00989A

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