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Issue 28, 2018
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Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

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Abstract

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

Graphical abstract: Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

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Publication details

The article was received on 20 Apr 2018, accepted on 29 Jun 2018 and first published on 06 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB00931G
Citation: Org. Biomol. Chem., 2018,16, 5113-5118
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    Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

    A. Murugan, K. R. Gorantla, B. S. Mallik and D. S. Sharada, Org. Biomol. Chem., 2018, 16, 5113
    DOI: 10.1039/C8OB00931G

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