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Issue 29, 2018
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Recent advances in the annulation of Morita–Baylis–Hillman adducts

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Abstract

In this review, we summarize some of the most recent advances in the construction of cyclic compounds from the annulation of Morita–Baylis–Hillman (MBH) adducts, which have demonstrated their importance by possessing diverse functional groups. Significant examples including [3 + 2], [3 + 3], [3 + 4] and other cyclizations described herein with MBH adducts were proven to be efficient approaches for the preparation of diverse cyclic structure motifs. However, most of the reported strategies are based on the use of non-chiral catalysts/ligands, whilst stereoselective reactions remain largely unexplored. This area is still in its infancy and future research on MBH adducts will definitely benefit the organic chemistry community, especially for the synthesis of drug candidates and other molecules that might draw attention to materials sciences.

Graphical abstract: Recent advances in the annulation of Morita–Baylis–Hillman adducts

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Publication details

The article was received on 20 Apr 2018, accepted on 24 Jun 2018 and first published on 25 Jun 2018


Article type: Review Article
DOI: 10.1039/C8OB00929E
Citation: Org. Biomol. Chem., 2018,16, 5214-5227
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    Recent advances in the annulation of Morita–Baylis–Hillman adducts

    N. Zhong, Y. Wang, L. Cheng, D. Wang and L. Liu, Org. Biomol. Chem., 2018, 16, 5214
    DOI: 10.1039/C8OB00929E

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