The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

Yixin Zhang; Haojie Ma; Xingxing Liu; Xinfeng Cui; Shaohua Wang; Zhenzhen Zhan; Jinghong Pu; Guosheng Huang

doi:10.1039/C8OB00899J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes†

Yixin Zhang,^a Haojie Ma,^a Xingxing Liu,^a Xinfeng Cui,^a Shaohua Wang,

^a Zhenzhen Zhan,^a Jinghong Pu^a and Guosheng Huang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: hgs@lzu.edu.cn

Abstract

A novel [3 + 2] cycloaddition reaction of azaoxyallyl cations and aromatic ethylenes has been developed to afford multi-substituted pyrrolidinones in moderate to good yields. This method not only further expands the synthetic utility of α-halo hydroxamates, but also provides an alternative method for the synthesis of bioactive molecules containing pyrrolidinones.

This article is part of the themed collection: Synthetic methodology in OBC

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C8OB00899J
Article type: Communication
Submitted: 17 Apr 2018
Accepted: 24 May 2018
First published: 25 May 2018

Download Citation

Org. Biomol. Chem., 2018,16, 4439-4442

Permissions

Request permissions

The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

Y. Zhang, H. Ma, X. Liu, X. Cui, S. Wang, Z. Zhan, J. Pu and G. Huang, Org. Biomol. Chem., 2018, 16, 4439 DOI: 10.1039/C8OB00899J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry

The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes†

Abstract

Supplementary files

Article information

Download Citation

Permissions

The synthesis of multi-substituted pyrrolidinones via a direct [3 + 2] cycloaddition of azaoxyallyl cations with aromatic ethylenes

Social activity

Search articles by author

Spotlight

Advertisements