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Issue 26, 2018
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Biosynthesis of the teleocidin-type terpenoid indole alkaloids

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Abstract

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. Its unique structure and bioactivity have drawn vast interest from chemists and biologists, and numerous isolation and bioactivity studies on this molecule have been performed. Recently, its biosynthetic enzymes were identified, and some of their crystal structures were reported. In this review, we describe the isolation of teleocidin derivatives, biosynthetic studies, and detailed analyses of biosynthetic enzymes, to clarify their biosynthetic reactions toward the enzymatic synthesis of bioactive teleocidin compounds.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids

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Publication details

The article was received on 05 Apr 2018, accepted on 14 May 2018 and first published on 14 May 2018


Article type: Review Article
DOI: 10.1039/C8OB00803E
Citation: Org. Biomol. Chem., 2018,16, 4746-4752
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    Biosynthesis of the teleocidin-type terpenoid indole alkaloids

    T. Awakawa and I. Abe, Org. Biomol. Chem., 2018, 16, 4746
    DOI: 10.1039/C8OB00803E

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