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Issue 21, 2018
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Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

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Abstract

A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing various functional groups are obtained in moderate to excellent yields.

Graphical abstract: Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

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Publication details

The article was received on 04 Apr 2018, accepted on 03 May 2018 and first published on 04 May 2018


Article type: Paper
DOI: 10.1039/C8OB00795K
Citation: Org. Biomol. Chem., 2018,16, 3983-3988
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    Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

    W. Weng, J. Xie and B. Zhang, Org. Biomol. Chem., 2018, 16, 3983
    DOI: 10.1039/C8OB00795K

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