Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2018
Previous Article Next Article

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

Author affiliations

Abstract

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner. Results of the preliminary studies are consistent with the recently described cell death mechanism ferroptosis. Studies are in progress to confirm ferroptosis as the cell death mechanism and to identify the specific molecular targets of these small molecule anticancer agents.

Graphical abstract: Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

Back to tab navigation

Supplementary files

Article information


Submitted
13 Dec 2017
Accepted
30 Jan 2018
First published
30 Jan 2018

Org. Biomol. Chem., 2018,16, 1465-1479
Article type
Paper

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

S. R. Fedorka, K. So, A. A. Al-Hamashi, I. Gad, R. Shah, V. Kholodovych, H. D. Alqahtani, W. R. Taylor and L. M. V. Tillekeratne, Org. Biomol. Chem., 2018, 16, 1465
DOI: 10.1039/C7OB03086J

Social activity

Search articles by author

Spotlight

Advertisements