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Bone remodeling-inspired dual delivery electrospun nanofibers for promoting bone regeneration


Developing highly bioactive bone tissue engineering scaffold that can modulate bone remodeling process for promoting bone regeneration is a great challenge. In order to tackle this issue, inspired by the balance between bone resorption and formation in bone remodeling process, here we developed a mesoporous silicate nanoparticles (MSNs)-based electrospun polycaprolactone (PCL)/gelatin nanofibrous scaffold to achieve dual delivery of alendronate (ALN) and silicate for synergetic effect on modulating bone remodeling, where ALN inhibited bone-resorbing process via preventing guanosine triphosphate-related protein expression, and silicate promoted bone-forming process via improving vascularization and bone calcification. The scaffold was successfully prepared by encapsulation of ALN into MSNs (ALN@MSNs) and co-electrospinning of acetic acid-mediated PCL/gelatin homogenous solution with well-dispersed ALN@MSNs. The results of ALN and Si element release profile indicated that the ALN@MSNs-loaded nanofibers achieved dual release of ALN and silicate (produced due to hydrolysis of MSNs) simultaneously. The bone repair data from rat critical-sized cranial defect model revealed that the developed strategy accelerated the healing time from 12 weeks to 4 weeks, as almost three times faster, while the other nanofiber groups only had limited bone regeneration at 4 weeks. In addition, we used interactive double-factor analysis of variance for the data of bone volume and maturity to evaluate the synergetic effect of ALN and silicate on promoting bone regeneration, and the result clearly proved our original design and hypothesis. In summary, the presented bone remodeling-inspired electrospun nanofibers with dual delivery of ALN and silicate may be highly promising for bone repair in clinic.

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Publication details

The article was received on 09 Sep 2018, accepted on 28 Sep 2018 and first published on 10 Oct 2018

Article type: Paper
DOI: 10.1039/C8NR07329E
Citation: Nanoscale, 2018, Accepted Manuscript
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    Bone remodeling-inspired dual delivery electrospun nanofibers for promoting bone regeneration

    Y. Wang, W. Cui, X. Zhao, S. Wen, Y. Sun, J. Han and H. Zhang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR07329E

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