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Issue 48, 2018
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The equilibrium structure of self-assembled protein nano-cages

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Understanding how highly symmetric, robust, monodisperse protein nano-cages self-assemble can have major applications in various areas of bio-nanotechnology, such as drug delivery, biomedical imaging and gene therapy. We develop a model to investigate the assembly of protein subunits into the structures with different sizes and symmetries. Using Monte Carlo simulation, we obtain global minimum energy structures. Our results suggest that the physical properties including the spontaneous curvature, flexibility and bending rigidity of coat proteins are sufficient to predict the size, symmetry and shape selectivity of the assembly products. Further, on a thermodynamic basis, we discuss the polymorphism of nano-cages observed in assembly experiments.

Graphical abstract: The equilibrium structure of self-assembled protein nano-cages

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Publication details

The article was received on 04 Sep 2018, accepted on 05 Nov 2018 and first published on 05 Dec 2018

Article type: Paper
DOI: 10.1039/C8NR07202G
Nanoscale, 2018,10, 22802-22809

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    The equilibrium structure of self-assembled protein nano-cages

    S. Panahandeh, S. Li and R. Zandi, Nanoscale, 2018, 10, 22802
    DOI: 10.1039/C8NR07202G

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