Jump to main content
Jump to site search


Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties

Author affiliations

Abstract

The use of antibiotics has been an epoch-making invention in the past few decades for the treatment of infectious diseases. However, the intravenous injection of antibiotics lacking responsiveness and targeting properties has led to low drug utilization and high cytotoxicity. More importantly, it has also caused the development and spread of drug-resistant bacteria due to repeated medication and increased dosage. The differences in the microenvironments of the bacterial infection sites and normal tissues, such as lower pH, high expression of some special enzymes, hydrogen peroxide and released toxins, etc., are usually used for targeted and controlled drug delivery. In addition, bacterial surface charges, antigens and the surface structures of bacterial cell walls are all different from normal tissue cells. Based on the special bacterial infection microenvironments and bacteria surface properties, a series of drug delivery systems has been constructed for highly efficient drug release. This review summarizes the recent progress in targeted and responsive drug delivery systems for enhanced antibacterial properties.

Graphical abstract: Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties

Back to tab navigation

Publication details

The article was received on 03 Sep 2018, accepted on 24 Oct 2018 and first published on 24 Oct 2018


Article type: Review Article
DOI: 10.1039/C8NR07146B
Citation: Nanoscale, 2018, Advance Article
  •   Request permissions

    Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties

    H. Chen, Y. Jin, J. Wang, Y. Wang, W. Jiang, H. Dai, S. Pang, L. Lei, J. Ji and B. Wang, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR07146B

Search articles by author

Spotlight

Advertisements