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Issue 39, 2018
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Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

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Abstract

Multidrug-resistant biofilms are highly resistant to current antimicrobial therapies. We have developed an antimicrobial platform that integrates the bacteria-killing phytochemical carvacrol into dynamically crosslinked polymer nanocomposites (DCPNs). Taking advantage of a reversibly crosslinked Schiff-base scaffold throughout the engineered emulsions, DCPNs exhibited long-term shelf-life and good stability in serum, while readily disassembling in acidic microenvironments. Furthermore, we demonstrated that DCPNs efficiently penetrate the biofilm matrix, eradicating both Gram-negative/positive bacteria enclosed within. Moreover, DCPNs showed no observable toxicity to fibroblast mammalian cells with the same antimicrobial concentrations necessary to eradicate MDR biofilms. Given their potent antimicrobial and stimuli-responsive dissociation characteristics in a biofilm setting, DCPNs are a suitable therapeutic platform for combating MDR bacterial infections.

Graphical abstract: Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

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Publication details

The article was received on 06 Aug 2018, accepted on 04 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR06348F
Citation: Nanoscale, 2018,10, 18651-18656
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    Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

    D. Y. Zhu, R. F. Landis, C. Li, A. Gupta, L. Wang, Y. Geng, S. Gopalakrishnan, J. W. Guo and V. M. Rotello, Nanoscale, 2018, 10, 18651
    DOI: 10.1039/C8NR06348F

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