Jump to main content
Jump to site search


Surface charge tunable catanionic vesicles based on serine-derived surfactants as efficient nanocarriers for the delivery of the anticancer drug doxorubicin

Abstract

Self-assembled vesicles composed by amino acid-based cationic/anionic surfactant mixtures show promise as novel effective drug nanocarriers. Here, we report the in vitro performance of vesicles based on cationic (16Ser) and anionic (8-8Ser) serine-based surfactants using a cancer cell model for the delivery of the anticancer drug doxorubicin (DOX). This catanionic mixture yields both negatively (0.20 in cationic surfactant molar fraction, x16Ser) and positively (x16Ser=0.58) charged vesicles, hence providing a surface charge tunable system. Low toxicity is confirmed for concentration ranges below 32 μM in both formulations. DOX is successfully encapsulated in the vesicles, resulting in a surface charge switch to negative for the (0.58) system, making both (0.20) and (0.58) DOX-loaded vesicles highly interesting for systemic administration. High uptake by cells was demonstrated using flow cytometry and confocal microscopy. Drug accumulation results in an increase of up to 250% and 200% for the (0.20) and (0.58) vesicles, respectively, compared to free DOX and with localizations near nuclear regions in the cells. The in vitro cytotoxicity studies show DOX-loaded vesicles induce cell death, confirming the therapeutic potential of the formulations. Furthermore, the efficient accumulation of the drug inside the cell compartments harbors the potential for optimization strategies including phased delivery for prolonged treatment periods or even on-demand release.

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Aug 2018, accepted on 25 Nov 2018 and first published on 05 Dec 2018


Article type: Paper
DOI: 10.1039/C8NR06346J
Citation: Nanoscale, 2018, Accepted Manuscript
  •   Request permissions

    Surface charge tunable catanionic vesicles based on serine-derived surfactants as efficient nanocarriers for the delivery of the anticancer drug doxorubicin

    R. C. Fonseca Gonçalves Lopes, O. F. Silvestre, A. R. Faria, M. L. Vale, E. F. Marques and J. B. Nieder, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR06346J

Search articles by author

Spotlight

Advertisements