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Structural shift of DNA template between hairpin and dimer tunes the emission color of DNA-templated AgNCs

Abstract

The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we here suggest that the structural shift of DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that structural shift post AgNCs formation can be triggered by incubation time and pre-AgNCs formation by salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures either with sequence changes or ionic condtions can be applied for dual-color detection system of a target molecule. Especially, the dual-color detection method may increase the reliablity of DNA/AgNCs sensors for miRNAs.

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Publication details

The article was received on 01 Aug 2018, accepted on 11 Oct 2018 and first published on 12 Oct 2018


Article type: Paper
DOI: 10.1039/C8NR06186F
Citation: Nanoscale, 2018, Accepted Manuscript
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    Structural shift of DNA template between hairpin and dimer tunes the emission color of DNA-templated AgNCs

    P. Shah, R. Nagda, S. W. Choi, R. Geczy, S. K. Cho, Y. Bhang, T. Kim, T. Y. Song, P. H. Lee, J. Kang, P. W. W. Thulstrup, M. J. Bjerrum, I. L. Jung and S. W. Yang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR06186F

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