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AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

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Abstract

Cancer development and progression are closely associated with changes both in the mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix (ECM) structure, composition, and mechanics. In this paper, we review the use of atomic force microscopy (AFM) as a tool for assessing the nanomechanical fingerprints of solid tumors, so as to be potentially used as a diagnostic biomarker for more accurate identification and early cancer grading/classification. The development of such a methodology is expected to provide new insights and a novel approach for cancer diagnosis. We propose that AFM measurements could be employed to complement standard biopsy procedures, offering an objective, novel and quantitative diagnostic approach with the properties of a blind assay, allowing unbiased evaluation of the sample.

Graphical abstract: AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

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Publication details

The article was received on 31 Jul 2018, accepted on 18 Oct 2018 and first published on 19 Oct 2018


Article type: Review Article
DOI: 10.1039/C8NR06146G
Citation: Nanoscale, 2018, Advance Article
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    AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

    A. Stylianou, M. Lekka and T. Stylianopoulos, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR06146G

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