Jump to main content
Jump to site search

Issue 43, 2018
Previous Article Next Article

An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

Author affiliations

Abstract

Computed tomography (CT) is one of the most frequently used diagnostic imaging modalities in clinics. However, the fast clearance of CT contrast agents through the kidney and short circulation time severely restrict their in vivo applications. Herein, taking advantage of the biocompatible CBT condensation reaction, we rationally designed and synthesized a new smart acidic pH/glutathione (GSH) dual-stimuli responsive nanoprobe (1) which can intermolecularly undergo condensation and form a nanoparticle assembly (I-NPs) in the tumour microenvironment. In vivo CT imaging results indicated that probe 1 could be successfully applied for enhanced CT imaging of tumours in nude mice with a low dose of 21.79 mg I per kg body weight, which may offer a promising tool for precise tumor diagnosis.

Graphical abstract: An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2018, accepted on 21 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8NR05061A
Citation: Nanoscale, 2018,10, 20126-20130
  •   Request permissions

    An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

    A. Wang, L. Yin, L. He, H. Xia, F. Chen, M. Zhao, J. Ding and H. Shi, Nanoscale, 2018, 10, 20126
    DOI: 10.1039/C8NR05061A

Search articles by author

Spotlight

Advertisements