Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

Shuai Zha; Yan Ho Fung; Ho-Fai Chau; Ping'an Ma; Jun Lin; Jing Wang; Lai Sheung Chan; Guang Zhu; Hong Lok Lung; Ka-Leung Wong

doi:10.1039/C8NR05015E

Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1†

Shuai Zha,

^a Yan Ho Fung,

^a Ho-Fai Chau,^ab Ping'an Ma,^c Jun Lin,

^c Jing Wang,

^d Lai Sheung Chan,^b Guang Zhu,

^e Hong Lok Lung

*^b and Ka-Leung Wong

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong S.A.R., P. R. China
E-mail: klwong@hkbu.edu.hk

^b Department of Biology, Hong Kong Baptist University, Kowloon, Hong Kong S.A.R., P. R. China
E-mail: hllung2@hkbu.edu.hk

^c State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China

^d Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China

^e Division of Life Science, Hong Kong University of Science and Technology, Kowloon, Hong Kong S.A.R., P. R. China

Abstract

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF₄:Yb³⁺,Er³⁺@NaGdF₄ (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein – EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core–shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

Nanoscale

Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1†

Abstract

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Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1

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