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Issue 30, 2018
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A water-soluble, upconverting Sr2Yb0.3Gd0.7F7:Er3+/Tm3+@PSIoAm bio-probe for in vivo trimodality imaging

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Abstract

Multi-modality in vivo bioimaging has great renown for offering more comprehensive information in medical diagnosis and research. Incorporating different bioimaging capabilities into one biocompatible nanoprobe requires an elegant structural design. Considering optical and magnetic properties, X-ray absorption ability, and clinical safety, we prepared a water-soluble and upconverting PSIoAm-modified Sr2Yb0.3Gd0.7F7:Er3+/Tm3+ bio-probe that not only had high photostability and excellent cell membrane permeability, but could also distinguish the four types of cancer cells and normal cells tested within the scope of our study. What's more, it could realize the in vivo trimodality imaging of upconversion fluorescence, X-ray computed tomography and magnetic resonance. The histological analysis of visceral sections further demonstrated that the multifunctional bio-probe was highly safe, which could be applied to clinical diagnosis.

Graphical abstract: A water-soluble, upconverting Sr2Yb0.3Gd0.7F7:Er3+/Tm3+@PSIoAm bio-probe for in vivo trimodality imaging

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Publication details

The article was received on 19 Apr 2018, accepted on 12 May 2018 and first published on 21 May 2018


Article type: Paper
DOI: 10.1039/C8NR03220C
Citation: Nanoscale, 2018,10, 14414-14420
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    A water-soluble, upconverting Sr2Yb0.3Gd0.7F7:Er3+/Tm3+@PSIoAm bio-probe for in vivo trimodality imaging

    L. Xiang, X. Zhu, H. Zhang, L. Yang, K. Deng, Y. Liu, M. Ye, L. Hu, X. Yang and H. Zhou, Nanoscale, 2018, 10, 14414
    DOI: 10.1039/C8NR03220C

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