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Issue 3, 2019
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Challenges in the configuration assignment of natural products. A case-selective perspective

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Abstract

Covering: up to 2018

Even today, when planar structures of natural products can be determined with microgram samples, the configurational assignment continues to be a challenge. The relative and absolute configurations of natural products can be assigned by devising original approaches, relying on carefully acquired data on a case-by-case basis. In this review, the most widely available methods and techniques for the absolute configuration determination of novel natural products are concisely discussed. Selected illustrative examples (case studies) are presented, where original approaches integrating different chemical, spectroscopic, and/or computational methods have been devised to solve intriguing stereochemistry issues of natural small molecules.

Graphical abstract: Challenges in the configuration assignment of natural products. A case-selective perspective

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Publication details

The article was received on 19 Jun 2018 and first published on 24 Sep 2018


Article type: Review Article
DOI: 10.1039/C8NP00053K
Citation: Nat. Prod. Rep., 2019,36, 476-489

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    Challenges in the configuration assignment of natural products. A case-selective perspective

    M. Menna, C. Imperatore, A. Mangoni, G. Della Sala and O. Taglialatela-Scafati, Nat. Prod. Rep., 2019, 36, 476
    DOI: 10.1039/C8NP00053K

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