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An Efficient Synthesis of Versatile Synthon 3-Chlorooxindoles with NaCl/Oxone

Abstract

The present work describes an expedient approach for the direct conversion of Indole-3-carboxaldehyde to 3-chlorooxindoles using a simple sustainable synthetic method. From environmental perspective, combination of NaCl/Oxone in CH3CN:H2O (1:1) system was developed for direct oxidative chlorination of a wide array of indole derivatives. This chlorination strategy is more viable, remarkably cheaper and provides easy access to potential 3-chlorooxindoles. In addition, this environmentally benign method can also be applicable for constructing isatin derivatives in good yields.

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Publication details

The article was received on 25 Sep 2018, accepted on 07 Nov 2018 and first published on 08 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ04855J
Citation: New J. Chem., 2018, Accepted Manuscript
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    An Efficient Synthesis of Versatile Synthon 3-Chlorooxindoles with NaCl/Oxone

    S. P. Parvathaneni, L. R. Vanammoolee, J. R. Vaidya and B. raktani, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04855J

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