Jump to main content
Jump to site search


An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination

Author affiliations

Abstract

Herein, we have reported a low cost simple aminoquinoline based pH sensor HL [HL = 2-methoxy-6-((quinolin-3-ylimino)methyl)phenol]. HL acts as a potential low pH fluorometric as well as colourimetric pH probe. In acidic media it is colourless whereas, in basic media, it is yellow in colour. HL is thoroughly characterized by different spectroscopic techniques viz. UV-visible, fluorescence, 1H and 13C NMR spectroscopy along with ESI-MS and elemental analysis. We are successful in elucidating the X-ray crystal structure of HL. Theoretical calculations such as DFT and TDDFT are also performed to support our experimental findings. The ability of this biocompatible pH sensor (HL) to differentiate normal and cancer cells by alteration of pH will open new vistas for various biomedical applications.

Graphical abstract: An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2018, accepted on 07 Nov 2018 and first published on 07 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ04753G
Citation: New J. Chem., 2018, Advance Article
  •   Request permissions

    An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination

    J. Mandal, P. Ghorai, P. Brandão, K. Pal, P. Karmakar and A. Saha, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ04753G

Search articles by author

Spotlight

Advertisements