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Cyclic iRGD Peptide as a Dual-Functional On-Off Gatekeeper of Mesoporous Nanocontainers for Targeting NRP-1 and Selective Drug Release Triggered by Conformational Conversion

Abstract

Adopting conformational conversion of peptide as a trigger to control on-off gatekeeping on the surface of mesoporous silica nanoparticles has several advantages. Here, we designed a dual-functional cyclic peptide with iRGD sequence for the stimulus-responsive on-off gatekeeper on the surface of mesoporous silica nanocontainers. The cyclic peptide gatekeeper with intramolecular disulfide bond between the two cysteine units at the both terminal of the peptide sequence exhibited selective drug release triggered by stimulus-induced conformational conversion. Furthermore, the iRGD sequence of cyclic peptide gatekeeper enhanced the intracellular uptake and therapeutic efficacy of the nanoparticles by specific binding with NRP-1 receptor on the surface of target cancer cells.

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Publication details

The article was received on 12 Sep 2018, accepted on 05 Dec 2018 and first published on 06 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ04649B
Citation: New J. Chem., 2018, Accepted Manuscript
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    Cyclic iRGD Peptide as a Dual-Functional On-Off Gatekeeper of Mesoporous Nanocontainers for Targeting NRP-1 and Selective Drug Release Triggered by Conformational Conversion

    J. Lee, E. Oh, J. Lee, T. Kang, H. G. Kim, H. Kang, H. J. Park and C. Kim, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04649B

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