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Issue 22, 2018
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A Rh(III)-catalyzed cascade C–H functionalization/cyclization reaction of salicylaldehydes with diazomalonates for the synthesis of 4-hydroxycoumarin derivatives

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Abstract

A cascade C–H functionalization/cyclization reaction of salicylaldehydes with α-diazomalonates has been developed for the synthesis of 4-hydroxycoumarin derivatives under the catalysis of rhodium(III) and in the presence of acetic acid. A plausible mechanism involving aldehydic C(sp2)–H activation by rhodium(III) and rhodium(III) catalyzed carbene insertion is also proposed.

Graphical abstract: A Rh(iii)-catalyzed cascade C–H functionalization/cyclization reaction of salicylaldehydes with diazomalonates for the synthesis of 4-hydroxycoumarin derivatives

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Publication details

The article was received on 09 Sep 2018, accepted on 08 Oct 2018 and first published on 23 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ04576C
Citation: New J. Chem., 2018,42, 18358-18362
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    A Rh(III)-catalyzed cascade C–H functionalization/cyclization reaction of salicylaldehydes with diazomalonates for the synthesis of 4-hydroxycoumarin derivatives

    G. Xu and Z. Huang, New J. Chem., 2018, 42, 18358
    DOI: 10.1039/C8NJ04576C

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