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Issue 4, 2019
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An I6P7 peptide modified fluorescent probe for bio-imaging

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Abstract

The I6P7 peptide was proved to specifically bind to the interleukin-6 receptor, which can be exploited as an effective tumor-targeting moiety. Herein, a novel tumor-targeting fluorescent probe (DMP) conjugated with the I6P7 peptide was designed and synthesized. This probe was validated to possess valuable photophysical properties. The biocompatibility was evaluated by investigating its cytotoxicity on HUVEC and U87 cells, respectively. The tumor cell affinity has been confirmed by bio-imaging of this probe on different human cancer cells (U87, A549 and MCF-7 cells) and normal cells (HUVEC cell). The probe demonstrates low cytotoxicity, high tumor cell affinity and favorable mitochondria-targeting capability. Overall, these results revealed that DMP can serve as an important fluorescent probe for tumor-targeted bio-imaging.

Graphical abstract: An I6P7 peptide modified fluorescent probe for bio-imaging

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Publication details

The article was received on 20 Aug 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ04255A
New J. Chem., 2019,43, 1785-1790

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    An I6P7 peptide modified fluorescent probe for bio-imaging

    Y. Yao, L. Gui, B. Gao, Z. Yuan, Y. Chen, C. Wei, Q. He, F. Wang, M. Xu and H. Chen, New J. Chem., 2019, 43, 1785
    DOI: 10.1039/C8NJ04255A

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