Jump to main content
Jump to site search


An I6P7 Peptide Modified Fluorescent Probe for Bio-imaging

Abstract

I6P7 peptide was proved to have specifically bind to interleukin-6 receptor, which can be exploited as an effective tumor-targeting moeity. Herein, a novel tumor-targeting fluorescence probe (DMP) conjugated with I6P7 peptide was designed and synthesized. This probe was validated to possess valuable photophysical properties. The biocompatibility was evaluted by cytoxicity on HUVEC and U87 cells repectively. The tumor cell affinity capability has been confirmed by bio-imaging of this probe on different human cancer cells (U87, A549 and MCF-7 cells) and normal cells (HUVEC cell). The probe demonstrates low cytotoxicity, high tumor cell affinity and favorable mitochondria-targeting capability. Overall, the results revealed that DMP can be served as an important fluorescence probe for tumor-targeting bioimaging.

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Aug 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8NJ04255A
Citation: New J. Chem., 2018, Accepted Manuscript
  •   Request permissions

    An I6P7 Peptide Modified Fluorescent Probe for Bio-imaging

    Y. Yao, L. Gui, Z. Yuan, Y. Chen, W. Chen, Q. He, F. Wang, M. Xu and H. Chen, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04255A

Search articles by author

Spotlight

Advertisements