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A novel long-wavelength fluorescent probe for selective detection of hydrogen sulfide in living cells

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Abstract

Hydrogen sulfide (H2S) plays a vital role as a critical biological messenger in numerous physiological and pathophysiological processes. It is necessary to detect H2S to obtain important physiological and pathological information. Here, a novel long-wavelength probe (LC-H2S) was developed based on the selective thiolysis reaction of dinitrophenyl ether. LC-H2S is nearly non-fluorescent (ΦF = 0.032), but the reaction product (LC-OH) emits strong fluorescence at 644 nm when excited at 571 nm (ΦF = 0.228). The long wavelength of LC-H2S makes it less susceptible to background fluorescence from biological matrices and to photo damage on fluorescence imaging of H2S. With the advantages of the turn-on probe for H2S including high sensitivity, high selectivity, good biocompatibility and low toxicity, the probe has been successfully used for imaging H2S in living cells.

Graphical abstract: A novel long-wavelength fluorescent probe for selective detection of hydrogen sulfide in living cells

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Publication details

The article was received on 19 Aug 2018, accepted on 23 Oct 2018 and first published on 24 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ04241A
Citation: New J. Chem., 2018, Advance Article
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    A novel long-wavelength fluorescent probe for selective detection of hydrogen sulfide in living cells

    Y. Li, X. Zhao, Y. Jiang and B. Yang, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ04241A

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