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Metal oxide nanoparticles Functionalized Sebacic Acid grafted PHEAM nanocarriers for enriched activity of Metronidazole against food borne bacteria: in vitro and in vivo study

Abstract

Food borne infection is the serious complications caused through Listeria monocytogenes (L. monocytogenes) as dangerous bacteria. Antibiotic is one of the remedy for the destruction of bacterial infection predominantly to target the bacterial cell, to minimize the side effects and to overcome the antibiotic resistance. In this present study, we have developed non-toxic, biocompatibility of metal oxide nanoparticles (Zinc oxide (ZnO), Magnesium oxide (MgO)) functionalized sebacic acid grafted poly 2-Hydroxy ethyl methacrylate (SA-g-PHEMA) with encapsulation of Metronidazole (MTZ) antibiotic drug. Nearly 99 % of drug encapsulation was obtained and releasing properties were investigated with different pH such as 1.2, 2.5, 5.5 and 7.4 and maximum drug releasing properties was attained in acidic pH (5.5). Functionality changes, surface modification, elemental analysis and plane orientation were investigated by using FTIR, SEM, TEM, EDX and XRD spectroscopy. Lesser MIC value of MgO-ZnO/SA-g-PHEMA-MTZ nanocarrier showed higher antibacterial activity. The 79 % of biofilm inhibition was obtained against MgO-ZnO/SA-g-PHEMA-MTZ in L. monocytogenes. Colony-forming unit (CFU) assay indicates the MgO-ZnO/SA-g-PHEMA-MTZ nanocarrier highly reduced the bacterial colonization on C. elegans worm.

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Publication details

The article was received on 25 Jul 2018, accepted on 08 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03718C
Citation: New J. Chem., 2018, Accepted Manuscript
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    Metal oxide nanoparticles Functionalized Sebacic Acid grafted PHEAM nanocarriers for enriched activity of Metronidazole against food borne bacteria: in vitro and in vivo study

    R. Mariappan, M. Gowri, S. Kannan, N. Latha, M. Marudhamuthu, M. Ahmed and A. A. Alarfaj, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03718C

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