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The synthesis of core–shell Cu9S5@mSiO2–ICG@PEG–LA for photothermal and photodynamic therapy

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Abstract

Recently, with strong NIR absorption, CuSx nanomaterials have been considered as potential photothermal and photodynamic anticancer agents. Herein, Cu9S5 nanoparticles were synthesized as the core and coated with mesoporous silica to construct the core–shell nanostructure (Cu9S5@mSiO2). The as-synthesized Cu9S5@mSiO2 nanomaterial possesses uniform sphere morphology, about 50 nm in size. Considering its ample porous structure, Cu9S5@mSiO2–NH2 was used as a nanocarrier to demonstrate the high loading efficiency of the photosensitizer indocyanine green (ICG). Under 808 nm NIR light illumination, the temperature rises to 55.8 °C (3 W cm−2), and the high photo-thermal converter is ascribed the combined action of Cu9S5 and ICG. Moreover, Cu9S5@mSiO2–ICG also reveals the illumination-dependent ROS generation. In addition, polyethylene glycol (PEG) and lactose acid (PEG–LA) was prepared and grafted outside Cu9S5@mSiO2–ICG to further guarantee the targeting and cell uptake performance. Under the synergistic effect of PTT and PDT, the Cu9S5@mSiO2–ICG@PEG–LA nanocomposite shows enhanced cytotoxicity to human hepatoma cells (HepG2), making it a promising candidate in nanomedicine as an antitumor agent.

Graphical abstract: The synthesis of core–shell Cu9S5@mSiO2–ICG@PEG–LA for photothermal and photodynamic therapy

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Publication details

The article was received on 25 Jul 2018, accepted on 01 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03712D
Citation: New J. Chem., 2018, Advance Article
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    The synthesis of core–shell Cu9S5@mSiO2–ICG@PEG–LA for photothermal and photodynamic therapy

    N. An, Y. Wang, M. Li, H. Lin and F. Qu, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ03712D

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