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Lemon juice mediated multicomponent reactions for the synthesis of fused imidazoles

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Abstract

A one-pot three component reaction mediated by lemon juice in an aqueous medium for the synthesis of diverse pharmaceutically important tricyclic fused imidazoles tethered with aryl and various cyclic 1,3-dicarbonyls has been reported. The reaction of arylglyoxals with cyclic 1,3-diacarbonyls such as N-methyl-4-hydroxyquinolone, 2,4-dihydroxyquinoline, 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone with various 1,3-N,N-binucleophiles such as 2-aminobenzothiazoles or 2-aminobenzimidazoles provided medicinally important diverse tricyclic fused imidazoles having aryl and cyclic 1,3-dicarbonyl substituents under metal-free conditions. This method is a natural acid catalyzed multicomponent reaction in an aqueous medium for the synthesis of diverse tricyclic fused imidazoles in good to excellent yields.

Graphical abstract: Lemon juice mediated multicomponent reactions for the synthesis of fused imidazoles

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Publication details

The article was received on 12 Jul 2018, accepted on 27 Sep 2018 and first published on 11 Oct 2018


Article type: Paper
DOI: 10.1039/C8NJ03480J
Citation: New J. Chem., 2018, Advance Article
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    Lemon juice mediated multicomponent reactions for the synthesis of fused imidazoles

    A. Saha, A. Jana and L. H. Choudhury, New J. Chem., 2018, Advance Article , DOI: 10.1039/C8NJ03480J

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