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Fabrication of curcumin loaded folic acid tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo system

Abstract

Curcumin has shown therapeutic activity against triple negative breast cancer cell (TNBC), but it shows low efficacy and low bioavailability when administered as a free drug. We have developed a general synthetic strategy to encapsulate the natural molecule curcumin in monodisperse isoreticular nanoscale metal organic frameworks (NMOF-3) nanoparticles for targeted drug delivery in triple negative breast cancer cells (TNBC). The cytotoxicity of IRMOF-3, curcumin loaded IRMOF-3 (IRMOF-3@CCM) and folic acid conjugated curcumin loaded IRMOF-3 (IRMOF-3@CCM@FA) in human and mice TNBC were tested. IF-MOF3@CCM@FA induces apoptosis by upregulating of Bax and down regulating of Bcl-2 and further it up regulates JNK and p53 in human TNBC cells. Simultaneously, we studied their effects in mice bearing TNBC induced by 4T1 cells. In in-vivo studies, mice receiving targeted delivery of curcumin had increased survivability and reduced tumor volume compared to non-targeted delivery. Our results highlight that folate-conjugated curcumin loaded IRMOF-3 may be a useful therapeutic agent to treat TNBC.

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Publication details

The article was received on 05 Jul 2018, accepted on 02 Nov 2018 and first published on 08 Nov 2018


Article type: Paper
DOI: 10.1039/C8NJ03350A
Citation: New J. Chem., 2018, Accepted Manuscript
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    Fabrication of curcumin loaded folic acid tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo system

    D. Laha, K. Pal, A. Ray Chowdhuri, P. K. Parida, S. K. Sahu, K. Jana and P. Karmakar, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ03350A

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